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Proceedings Paper

Treatment planning for photodynamic therapy: semi-empirical model and clinical trials on head and neck carcinoma
Author(s): Leonard I. Grossweiner; Barry L. Wenig; Rocco V. Lobraico
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Paper Abstract

An optical dosimetry model for photodynamic therapy (PDT) is based on the assumption that the tumor-localized photosensitizer must absorb an energy density threshold for tumor necrosis. The relationship between delivered dose and absorbed energy was calculated for idealized geometries with the photon diffusion equation and calibrated by scaling to PDT results for superficial tumors. The predictions of the model are compared with clinical trials on head and neck malignancies.

Paper Details

Date Published: 1 July 1990
PDF: 9 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17651
Show Author Affiliations
Leonard I. Grossweiner, Illinois Institute of Technology and Ravenswood Medical Ctr. (United States)
Barry L. Wenig, Univ of Illinois College of Medicine at Chicago (United States)
Rocco V. Lobraico, Ravenswood Hospital Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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