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Proceedings Paper

Photodetection of early cancer by laser-induced fluorescence of a tumor-selective dye: apparatus design and realization
Author(s): Georges A. Wagnieres; Christian D. Depeursinge; Philippe Monnier; Jean-Francois Savary; Piet Francois Cornaz; Andre Chatelain; Hubert van den Bergh
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Paper Abstract

An apparatus is designed and realized to detect "early" cancer at the surface of the hollow organs in the human body by endoscopic means. The tumor is localized by the laser induced fluorescence of a dye (HPD) which concentrates selectively in the neoplastic tissue after intravenous injection. Fluorescence contrast between the tumor and its normal surroundings is enhanced by subtracting the background autofluorescence which occurs in both types of tissue. This is done by means of 2-color digital images manipulation in real-time. Preliminary clinical tests of the apparatus demonstrated the detection of carcinoma in situ in the esophagus.

Paper Details

Date Published: 1 July 1990
PDF: 10 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17649
Show Author Affiliations
Georges A. Wagnieres, Swiss Federal Institute of Technology (Switzerland)
Christian D. Depeursinge, Swiss Federal Institute of Technology (Switzerland)
Philippe Monnier, CHUV Hospital (Switzerland)
Jean-Francois Savary, CHUV Hospital (Switzerland)
Piet Francois Cornaz, Swiss Federal Institute of Technology (Switzerland)
Andre Chatelain, Swiss Federal Institute of Technology (Switzerland)
Hubert van den Bergh, Swiss Federal Institute of Technology (Switzerland)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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