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Proceedings Paper

Diagnosis of tumors by fluorescence: quantification of photosensitizer concentration
Author(s): A. Edward Profio; Shusen Xie; Kuang-Hsien Shu
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Paper Abstract

The concentration of Photofrmn II is needed to determine the dose in photodynamic therapy, and in fluorescence diagnosis of tumors. A method based on fluorescence was devised which shows promise. Diffusion theory was applied in slab geometry with closely spaced excitation and emission wavelengths. A function of the measured radiant energy fluences for excitation and emission, and the depth x, was found that canceled the dependence on depth. A function of the diffusion coefficient and attenuation coefficient was derived from the measured diffuse reflectance. This function compensated for differences in absorption and scattering in different tissues, or a calibration phantom and tissue. Comparisons should be made with the concentration derived in other ways, but the fluorescence method shows promise.

Paper Details

Date Published: 1 July 1990
PDF: 7 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17646
Show Author Affiliations
A. Edward Profio, Univ. of California/Santa Barbara (United States)
Shusen Xie, Univ. of California/Santa Barbara (United States)
Kuang-Hsien Shu, Univ. of California/Santa Barbara (United States)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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