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Proceedings Paper

Photochemical and thermal changes in tissue autofluorescence during excimer laser irradiation
Author(s): Daniel J. McAuliffe; Steven L. Jacques; Amy S. Hayes
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Paper Abstract

A striking consequence of 248-nm excimer laser irradiation of skin is a stable vivid blue fluorescence easily visualized under UVA illumination. Its spectral properties (excitation maximum at "335 nm; emission maximum at ''43O nm) are somewhat similar to those of the fluorescent pigments associated with aging of tissue and peroxidation of lipids, and the fluorescent pigments formed during exposure to high temperatures. This study explores the spectral properties, magnitude, dose response, and laser pulse intensity dependence of this phenomenon in both isolated stratum corneum and epidermal cell suspensions from human skin.

Paper Details

Date Published: 1 June 1990
PDF: 10 pages
Proc. SPIE 1202, Laser-Tissue Interaction, (1 June 1990); doi: 10.1117/12.17615
Show Author Affiliations
Daniel J. McAuliffe, Harvard Medical School and Massachusetts General Hospital (United States)
Steven L. Jacques, Harvard Medical School and Massachusetts General Hospital (United States)
Amy S. Hayes, Massachusetts Institute of Technology (United States)

Published in SPIE Proceedings Vol. 1202:
Laser-Tissue Interaction
Steven L. Jacques, Editor(s)

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