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Proceedings Paper

Monitoring the efficiency of photodynamic therapy in tissue
Author(s): Arie Orenstein; Sol Kimel; Bruce J. Tromberg; J. Stuart Nelson; Michael W. Berns
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Paper Abstract

Transcutaneous oxygen electrodes are used to non-invasively measure tissue oxygen tension during photodynamic therapy (PDT). Measurements are performed on VX-2 skin carcinomas in rabbit ears. The degree of tumor oxygen tension reduction is proportional to the applied light dose. In the absence of irradiation, oxygen tension returns to pre-irradiation levels until a "damage threshold" has been reached. For 50mW/cm2 irradiations of Photofrmn II (at 630 nm) and tetraphenylporphine tetrasulfonate (at 657 tim), the cumulative dose required to irreversibly deplete tumor iranscutaneous oxygen was approximately 300 kJ/M2 and 600 kJ/M2, respectively.

Paper Details

Date Published: 1 June 1990
PDF: 5 pages
Proc. SPIE 1202, Laser-Tissue Interaction, (1 June 1990); doi: 10.1117/12.17614
Show Author Affiliations
Arie Orenstein, Sheba Medical Ctr. (Israel)
Sol Kimel, Technion--Israel Institute of Technology (Israel)
Bruce J. Tromberg, Univ. of California/Irvine (United States)
J. Stuart Nelson, Univ. of California/Irvine (United States)
Michael W. Berns, Univ. of California/Irvine (United States)


Published in SPIE Proceedings Vol. 1202:
Laser-Tissue Interaction
Steven L. Jacques, Editor(s)

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