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Proceedings Paper

Surface-enhanced Raman spectroscopy of peptides
Author(s): Robin L. Garrell; Tonya M. Herne; Angela M. Ahern; Eve L. Sullenberger
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Paper Abstract

Surface-enhanced Raman (SER) spectroscopy has been used to probe the adsorption, surface interactions, and orientations of peptides on metal surfaces. Amino acids in homodipeptides give SER spectra with unique features that can be used to characterize the surface interactions of specific functional groups in more complicated peptides. In heterodipeptides, there is a hierarchy of functional group-surface interactions that prescribe their orientation and conformation on metal surfaces. By establishing this hierarchy, it is now possible to predict the interactions that occur between larger peptides and surfaces. Furthermore, the observed trends suggest that it should be possible to control these interactions by varying the solution pH, the charge on the surface, and other parameters of the measurement in order to adsorb species selectively from mixtures of peptides in solution. Potential biomedical applications of this technique will be described.

Paper Details

Date Published: 1 July 1990
PDF: 10 pages
Proc. SPIE 1201, Optical Fibers in Medicine V, (1 July 1990); doi: 10.1117/12.17604
Show Author Affiliations
Robin L. Garrell, Univ. of Pittsburgh (United States)
Tonya M. Herne, Univ. of Pittsburgh (United States)
Angela M. Ahern, Univ. of Pittsburgh (United States)
Eve L. Sullenberger, Univ. of Pittsburgh (United States)


Published in SPIE Proceedings Vol. 1201:
Optical Fibers in Medicine V
Abraham Katzir, Editor(s)

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