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Proceedings Paper

Early cancer diagnosis using a diode laser and fiber optic system
Author(s): Winston Ho; Peter W. Low
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Paper Abstract

An ultrasensitive fiberoptic sensor using a near-IR fluorescence drug was developed for early cancer detection. Due to the use of long wavelength excitation at 670 nm with a diode laser, no measurable background fluorescence was observed. The system was built and successfully demonstrated in-vitro with a great drug sensitivity and tumor size resolution. The system, consisting of fiber probe, grating, and CCD optoelectronic components, is highly integrated. Based on fluorescence signature, tumors can be detected in real time. The flexible fiber with excellent light collection efficiency could be inserted into a human body through the working channel of an endoscope to map the metastatic region.

Paper Details

Date Published: 19 May 1994
PDF: 10 pages
Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.176010
Show Author Affiliations
Winston Ho, Physical Optics Corp. (United States)
Peter W. Low, Physical Optics Corp. (United States)


Published in SPIE Proceedings Vol. 2135:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases
Robert R. Alfano, Editor(s)

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