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Proceedings Paper

Noninvasive identification of bladder cancer with subsurface backscattered light
Author(s): Irving J. Bigio; Judith R. Mourant; James D. Boyer; Tamara M. Johnson; Tsutomu Shimada; Richard L. Conn
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Paper Abstract

We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. Absorption bands in the tissue also add useful complexity to the spectral data collected. The data acquisition and storage/display time with the OBS instrument is approximately 1 second. Thus, in addition to the reduced invasiveness of this technique compared with current state-of- the-art methods, the OBS offers the possibility of impressively faster diagnostic assessment. The OBS employs a small fiber-optic probe that is amendable to use with any endoscope, catheter or hypodermic, or to direct surface examination (e.g., as in skin cancer or cervical cancer). We report here specifically on its potential application in the detection of bladder cancer.

Paper Details

Date Published: 19 May 1994
PDF: 10 pages
Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.176000
Show Author Affiliations
Irving J. Bigio, Los Alamos National Lab. (United States)
Judith R. Mourant, Los Alamos National Lab. (United States)
James D. Boyer, Los Alamos National Lab. (United States)
Tamara M. Johnson, Los Alamos National Lab. (United States)
Tsutomu Shimada, Los Alamos National Lab. (United States)
Richard L. Conn, Lovelace Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2135:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases
Robert R. Alfano, Editor(s)

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