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Proceedings Paper

Time-resolved optical diffusion tomography
Author(s): C. Robert Appledorn; Robert A. Kruger; Pingyu Liu
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Paper Abstract

A mathematical model is proposed describing time-resolved output measurements obtained on the surface of a diffusely scattering body due to an input pulse of near-IR light at a different location also on the surface. Such measurements can be obtained using a pulsed near-IR laser coupled with a CCD streak camera. The scattering body is assumed to exhibit homogenous scattering and spatially varying absorption. Using this model, an iterative algorithm is derived using maximum likelihood methods that allows the reconstruction of the spatial absorption pattern from a set of time-resolved tomographic measurements. The methodology places no restrictions upon the time-of-arrival of the detected photons, thus permitting the entire time-resolved signal to be used in the reconstruction process. The reconstruction algorithm is easily initialized and preliminary results indicate that stable reconstructions can be performed.

Paper Details

Date Published: 19 May 1994
PDF: 13 pages
Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.175996
Show Author Affiliations
C. Robert Appledorn, Indiana Univ. School of Medicine (United States)
Robert A. Kruger, Indiana Univ. School of Medicine (United States)
Pingyu Liu, Indiana Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 2135:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases
Robert R. Alfano, Editor(s)

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