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Proceedings Paper

Application of the adjoint method to Monte Carlo studies of fluorescent localization in turbid media
Author(s): Richard J. Crilley; Wai-Fung Cheong; Brian C. Wilson; J. Richard Spears
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Paper Abstract

The present work has modeled fluorophore detection in optically turbid (absorbing and scattering) media by Monte Carlo simulation to determine the response functions for the single source/single detector case. This included application of the 'adjoint' Monte Carlo technique, as well as equivalent cylindrical models for noncylindrically symmetric geometries, which have reduced the computation time significantly. The case of fluorescent layer at depth in an optically homogeneous medium was then modeled and an image backprojection algorithm applied to estimate the depth of the fluorescent layer. The influence of tissue albedo, source- detector spacing, and detector numerical aperture on the depth accuracy and resolution have been examined. Possible improvements in multifiber detection for fluorescence quantification and localization within tissue are discussed.

Paper Details

Date Published: 19 May 1994
PDF: 12 pages
Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.175984
Show Author Affiliations
Richard J. Crilley, Wayne State Univ. School of Medicine (United States)
Wai-Fung Cheong, Wayne State Univ. School of Medicine (United States)
Brian C. Wilson, Univ. of Toronto (Canada)
J. Richard Spears, Wayne State Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 2135:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases
Robert R. Alfano, Editor(s)

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