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Proceedings Paper

Magnetic resonance imaging and spectroscopy to monitor and control experimental laser surgery
Author(s): Ferenc A. Jolesz; Alan R. Bleier; Nobuya Higuchi; Gregory J. Moore; Robert V. Mulkern; Peter D. Jakab; Vincent M. Colucci
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Paper Abstract

We have proposed the use of MRI for monitoring and control of interstitial laser surgery, in order to improve the accuracy and reduce the invasiveness of these procedures. To expand the knowledge base about the MR appearance of laser-induced tissue damage, we applied MR imaging and phosphorus-31 MR spectroscopy to detect the changes induced in various tissues by radiation from an Nd:YAG laser at 1060 nm wavelength delivered interstitially through a fiber optic waveguide. A range of laser energies was applied, and laser pulse parameters were varied. Proton MR images of the laser-produced lesions were compared with the histological appearance in brain and liver tissue of experimental animals. The spatial extent of laser effects differed among tissue types, and this was well reflected on MR images. The distribution of MR signal change resulting from different laser exposures was also demonstrated. Experimental laser surgery was performed in animal brain and bladder. Images taken before, during, and after laser irradiation allowed us to distinguish between reversible thermal and permanent effects. This information was utilized to tailor the destruction of preselected targets while minimizing damage to surrounding tissues. Qualitative changes were also revealed on phosphorus spectra. Irreversible lesions were characterized by overall line broadening and a decrease in AT?. There was also a large relative increase in the inorganic phosphate region of the spectrum. These demonstrations are a big step toward achieving our ultimate goal, the development of MR-controlled laser surgery.

Paper Details

Date Published: 1 June 1990
PDF: 4 pages
Proc. SPIE 1200, Laser Surgery: Advanced Characterization, Therapeutics, and Systems II, (1 June 1990); doi: 10.1117/12.17493
Show Author Affiliations
Ferenc A. Jolesz, Harvard Medical School and Brigham and Women's Hospital (United States)
Alan R. Bleier, Harvard Medical School and Brigham and Women's Hospital (United States)
Nobuya Higuchi, Harvard Medical School and Brigham and Women's Hospital (United States)
Gregory J. Moore, Harvard Medical School and Brigham and Women's Hospital (United States)
Robert V. Mulkern, Harvard Medical School and Brigham and Women's Hospital (United States)
Peter D. Jakab, Harvard Medical School and Brigham and Women's Hospital (United States)
Vincent M. Colucci, Harvard Medical School and Brigham and Women's Hospital (United States)


Published in SPIE Proceedings Vol. 1200:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems II
Stephen N. Joffe; Kazuhiko Atsumi, Editor(s)

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