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Proceedings Paper

Pulsed laser radiation effects on the distribution of conduction velocities in sciatic nerve of the rat
Author(s): Shien-Fong Lin; Ursula Wesselmann; William Zev Rymer
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Paper Abstract

The effects of subablative Q-switched Nd-YAG laser irradiation on the nerve fiber population of the sciatic nerve in rat were estimated using a quantitative method. The acute and cumulative effects were evaluated separately. When 5-minute laser irradiation was applied to the sciatic nerve, there was a differential decrease in the number of active fibers in slow and fast fiber classes. Fast fibers were insensitive to the radiation as the number of fibers was not altered significantly except at high radiating energies. The amount of decrease in each fiber class was not strictly proportional to the radiating laser energy. The cumulative effects show an exponential decay in fiber number after radiation sequence of gradually incremented laser pulse energy. Similarly, the impairment of fast fiber classes was less significant than slow fiber classes. At high cumulative optical energy, the number of fibers in fast fiber classes started decreasing whereas fiber population in slow fiber classes increased. We postulate that the impairment of the node of Ranvier was the dominant mechanism at lowenergy radiation, whereas the change in the cable properties of internodes resulted in the shift of fast fibers to slower fiber classes.

Paper Details

Date Published: 1 June 1990
PDF: 9 pages
Proc. SPIE 1200, Laser Surgery: Advanced Characterization, Therapeutics, and Systems II, (1 June 1990); doi: 10.1117/12.17475
Show Author Affiliations
Shien-Fong Lin, Chicago Institute of Neurosurgery and Neuroresearch and Northwestern University Medical School (United States)
Ursula Wesselmann, Chicago Institute of Neurosurgery and Neuroresearch and Northwestern University Medical School (United States)
William Zev Rymer, Chicago Institute of Neurosurgery and Neuroresearch and Northwestern University Medical School (United States)


Published in SPIE Proceedings Vol. 1200:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems II
Stephen N. Joffe; Kazuhiko Atsumi, Editor(s)

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