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Proceedings Paper

Photodynamic therapy of hypervascular cutaneous tissues in animal models using porphyrin or phthalocyanine activated by red light
Author(s): J. Stuart Nelson; Arie Orenstein; Lih-Huei L. Liaw; Sol Kimel; Michael W. Berns
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Paper Abstract

Continued iraprovement in the results of laser treatment of portwine stain (PWS) , with reduction in scarring, will depend on the ability to use lasers to induce selective injury of only the abnormal blood vessels in the dennis . Photodynamic therapy (PDT), using an exogenous photosensitizing drug specifically activated by a certain wavelength of light, may be used to destroy selectively certain targets in biological systems. The current study demonstrates, in the chicken comb animal model, that PDT using porphyrins and phthalocyanines activated by red light could be used to treat hypervascular derinal tissues.

Paper Details

Date Published: 1 June 1990
PDF: 10 pages
Proc. SPIE 1200, Laser Surgery: Advanced Characterization, Therapeutics, and Systems II, (1 June 1990); doi: 10.1117/12.17453
Show Author Affiliations
J. Stuart Nelson, Beckman Laser Institute and Medical Clinic/Univ. of California, Irvine (United States)
Arie Orenstein, Beckman Laser Institute and Medical Clinic/Univ. of California, Irvine (United States)
Lih-Huei L. Liaw, Beckman Laser Institute and Medical Clinic/Univ. of California, Irvine (United States)
Sol Kimel, Beckman Laser Institute and Medical Clinic/Univ. of California, Irvine (United States)
Michael W. Berns, Beckman Laser Institute and Medical Clinic/Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 1200:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems II
Stephen N. Joffe; Kazuhiko Atsumi, Editor(s)

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