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Proceedings Paper

Biodegradable radiopaque microspheres for the evaluation of regional pulmonary blood flow distribution using electron-beam computed tomography
Author(s): Michael J. Workman; Jehangir K. Tajik; Miguel T. Robinson; Eric A. Hoffman
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Paper Abstract

Accurate measurement of regional pulmonary blood flow distribution is of interest both as a research and diagnostic tool. Measurements of regional pulmonary perfusion via x-ray CT offer the possibility of detecting perfusion deficits due to pulmonary embolus while maintaining a high degree of anatomic detail. Use of bolus injection of conventional radiopaque contrast with associated short mean transit times (5 - 7 seconds), requires a high degree of temporal resolution offered clinically only by electron beam x-ray CT (Imatron). The present study was intended to characterize biodegradable radiopaque microspheres as an alternative contrast agent which would allow for measurement of regional pulmonary blood flow with scanning times associated with conventional or spiral thin slice, volumetric x-ray CT protocols. To test this, a dog was scanned at 6 slice levels and 13 time points with image acquisition gated to the cardiac cycle. Lung volumes were maintained at functional residual capacity.

Paper Details

Date Published: 1 May 1994
PDF: 13 pages
Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174413
Show Author Affiliations
Michael J. Workman, Univ. of Iowa College of Medicine (United States)
Jehangir K. Tajik, Univ. of Iowa College of Medicine (United States)
Miguel T. Robinson, Univ. of Iowa College of Medicine (United States)
Eric A. Hoffman, Univ. of Iowa College of Medicine (United States)


Published in SPIE Proceedings Vol. 2168:
Medical Imaging 1994: Physiology and Function from Multidimensional Images
Eric A. Hoffman; Raj S. Acharya, Editor(s)

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