Share Email Print
cover

Proceedings Paper

Contributions of statistical noise to spatial heterogeneity of PET images of pulmonary function
Author(s): Jose Gabriel Venegas; Steven Treppo; Srboljub Mijailovich
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We have recently developed methodologies to assess the local distributions of alveolar ventilation and pulmonary perfusion using positron emission tomography (PET) with 13NN gas as a tracer. In order to quantify the true regional heterogeneity in lung function from these images, it was important to assess the contributions of noise caused by finite count statistics and by imaging artifacts. To characterize these artifacts we collected multiple images with different total number of counts from a uniform phantom labeled with 11CO2 and assessed their heterogeneity as the mean normalized variance of the pixel by pixel data. We developed a novel disc phantom made of open cell foam with a density comparable to that of the lungs. Images of this phantom were reconstructed with a Hanning filter set for different resolution lengths (L). The mean normalized variance of these images was found to closely follow a linear relationship with the inverse of the average number of counts per pixel and L-3 having an intercept that represented the heterogeneity caused by imaging and reconstruction artifacts.

Paper Details

Date Published: 1 May 1994
PDF: 8 pages
Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174410
Show Author Affiliations
Jose Gabriel Venegas, Massachusetts General Hospital and Harvard Medical School (United States)
Steven Treppo, Massachusetts General Hospital and Harvard Medical School (United States)
Srboljub Mijailovich, Massachusetts General Hospital and Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 2168:
Medical Imaging 1994: Physiology and Function from Multidimensional Images
Eric A. Hoffman; Raj S. Acharya, Editor(s)

© SPIE. Terms of Use
Back to Top