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Proceedings Paper

Feasibility of using high-speed electron beam x-ray CT (EBCT) to follow the time course of the pulmonary response to pneumonectomy in rabbits
Author(s): L. E. Olson; V. P. Wright; Eric A. Hoffman
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Paper Abstract

This report focuses on preliminary experiments designed to determine regional blood flows and air, blood, and tissue contents at end expiratory lung volume in anesthetized, paralyzed, normal, sham-operated, and pneumonectomized (left lung removed) rabbits with and without wax plombage. High temporal resolution measurements were made with an EBCT scanner during the mechanical injection of a bolus of radiopaque contrast material into the pulmonary vasculature. The time-intensity curves of selected lung regions were analyzed with VIDAR using a modification of the myocardial blood flow model proposed by Wolfkiel et al. The resulting data provided an estimate of regional blood flow and total and regional air, blood and `tissue' contents, where `tissue' represents intracellular and interstitial water, i.e., lung water exclusive of blood. The estimates of mean lung air, blood and tissue contents were similar across groups and consistent with anticipated results.

Paper Details

Date Published: 1 May 1994
PDF: 12 pages
Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174408
Show Author Affiliations
L. E. Olson, The Ohio State Univ. (United States)
V. P. Wright, The Ohio State Univ. (United States)
Eric A. Hoffman, Univ. of Iowa College of Medicine (United States)


Published in SPIE Proceedings Vol. 2168:
Medical Imaging 1994: Physiology and Function from Multidimensional Images
Eric A. Hoffman; Raj S. Acharya, Editor(s)

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