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Proceedings Paper

Three-dimensional lung morphogenesis and fractal analysis as tools for the quantification of lung disease
Author(s): Jiang Qian; Theophano Mitsa
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Paper Abstract

The bronchial tree is one of the most well known fractal structures in the human body. Fractal objects like the bronchial tree have complex structures with self-similar properties over different scales. In this paper, we present a 3-D bronchial tree computer model constructed using fractal growth rules and actual morphometric data. Given the important role that the chest walls play in lung morphogenesis, the growth of the model was constrained within a 3-D boundary extracted from high resolution CT (HRCT) lung data. The model was built within a space of (512 X 512 X 512) pixels, and it currently models only the right lung. The parameters of the model are: (1) the diameter, d, of a branch; (2) the length, l, of a branch; (3) the angle, (theta) , between a branch and its parent. Utilizing this model as a testground, we developed a functional relationship between different changes in the morphology of the bronchial tree and the values of its 3-D fractal dimension and 3-D lacunarity.

Paper Details

Date Published: 1 May 1994
PDF: 11 pages
Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174407
Show Author Affiliations
Jiang Qian, Univ. of Iowa (United States)
Theophano Mitsa, Univ. of Iowa (United States)

Published in SPIE Proceedings Vol. 2168:
Medical Imaging 1994: Physiology and Function from Multidimensional Images
Eric A. Hoffman; Raj S. Acharya, Editor(s)

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