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Proceedings Paper

Extent of left ventricular systolic dysfunction during acute coronary occlusion is load dependent
Author(s): Robert M. Weiss
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Paper Abstract

When analysis of global and regional left ventricular function is utilized to assess ischemic zone size, it is assumed: (1) a predictable relationship exists between the two; and (2) this relationship is not significantly affected by changes in loading conditions. This study examined the relationship between ischemic zone size and ventricular performance in 11 anesthetized paced dogs subjected to acute coronary occlusion. Cardiac cine-computed tomography was used to quantify regional and global left ventricular function. Ischemic zone size was quantified autoradiographically following left atrial microsphere injection. Both global and regional left ventricular function were strongly influenced by changes in ventricular loading. We conclude: (1) both global and regional left ischemic dysfunction are only modestly correlated with ischemic zone size during acute coronary occlusion; and (2) estimates of ischemic zone size using measurements of ventricular function are highly load-sensitive.

Paper Details

Date Published: 1 May 1994
PDF: 22 pages
Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174391
Show Author Affiliations
Robert M. Weiss, Univ. of Iowa College of Medicine (United States)


Published in SPIE Proceedings Vol. 2168:
Medical Imaging 1994: Physiology and Function from Multidimensional Images
Eric A. Hoffman; Raj S. Acharya, Editor(s)

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