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Proceedings Paper

Toward reliable, noninvasive measurement of myocardial function from 4D images
Author(s): James S. Duncan; Peng-Cheng Shi; Amir A. Amimi; R. Todd Constable; Lawrence H. Staib; Donald Dione; QingXin Shi; Elliot K. Heller; Michael Singer; Amit Chakraborty; Glynn P. Robinson; John C. Gore; Albert J. Sinusas
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Paper Abstract

This paper describes efforts aimed at more accurately and objectively determining and quantifying the local, regional, and global function of the left ventricle (LV) of the heart under both normal and ischemic conditions. These measurements and evaluations are made using non-invasive, 3-D, cardiac diagnostic imaging sequences (i.e., 4-D data) and rely on an approach that follows the shape properties of the endocardial and epicardial surfaces of the LV over the entire cardiac cycle. Our efforts involve the development of an acute infarct animal model that permits us to establish the validity of our noninvasive image analysis algorithms, as well as permits us to study the efficacy of using in vivo, image-derived measures of function for predicting regional myocardial viability (immediately post mortem). We first describe the experimental setup for the animal model, including the use of implanted imaging-opaque markers that assist in setting up a gold standard against which image-derived measurements can be evaluated. Next, the imaging techniques are described, and finally the image analysis methods and their comparison to the validation technique are discussed.

Paper Details

Date Published: 1 May 1994
PDF: 13 pages
Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174390
Show Author Affiliations
James S. Duncan, Yale Univ. (United States)
Peng-Cheng Shi, Yale Univ. (United States)
Amir A. Amimi, Yale Univ. (United States)
R. Todd Constable, Yale Univ. (United States)
Lawrence H. Staib, Yale Univ. (United States)
Donald Dione, Yale Univ. (United States)
QingXin Shi, Yale Univ. (United States)
Elliot K. Heller, Yale Univ. (United States)
Michael Singer, Yale Univ. (United States)
Amit Chakraborty, Yale Univ. (United States)
Glynn P. Robinson, Yale Univ. (United States)
John C. Gore, Yale Univ. (United States)
Albert J. Sinusas, Yale Univ. (United States)


Published in SPIE Proceedings Vol. 2168:
Medical Imaging 1994: Physiology and Function from Multidimensional Images
Eric A. Hoffman; Raj S. Acharya, Editor(s)

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