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Proceedings Paper

Tracheal anastomosis using indocyanine green dye enhanced fibrinogen with a near-infrared diode laser
Author(s): Joseph S. Auteri; Valluvan Jeevanandam; Mehmet Cengiz Oz; Steven K. Libutti; Thomas J. Kirby; Craig R. Smith; Michael R. Treat
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Paper Abstract

A major obstacle to lung transplantation and combined heart- lung transplantation is dehiscence of the tracheobronchial anastomosis. We explored the possibility of laser welded anastomoses in canine tracheas in vivo. Laser anastomoses were performed on three-quarter circumferential anterior tracheotomies. A continous wave diode laser (808 +1 nm) at a power density of 9.6 watts/cm was used. Human fibrinogen was mixed with indocyanine green dye (ICG, max absorbance 805 nm) and applied to the anastomosis site prior to laser exposure. Animals were sacrificed at 0, 21 and 28 days post-operatively. At sacrifice weld bursting pressures were measured by raising intratracheal pressure using forced ventilation via an endotracheal tube. Sutured and laser welded anastomoses had similar bursting pressures, and exhibited satisfactory histologic evidence of healing. However, compared to polypropylene sutured controls, the laser welded anastomoses exhibited less peritracheal inflammatory reaction and showed visibly smoother luminal surfaces at 21 and 28 days post- operatively. Tracheal anastomosis using ICG dye enhanced fibrinogen combined with the near-infrared diode laser is a promising extension of the technology of laser tissue fusion and deserves further study.

Paper Details

Date Published: 1 June 1990
PDF: 4 pages
Proc. SPIE 1200, Laser Surgery: Advanced Characterization, Therapeutics, and Systems II, (1 June 1990); doi: 10.1117/12.17431
Show Author Affiliations
Joseph S. Auteri, Columbia Univ. College of Physicians and Surgeons (United States)
Valluvan Jeevanandam, Columbia Univ. College of Physicians and Surgeons (United States)
Mehmet Cengiz Oz, Columbia Univ. College of Physicians and Surgeons (United States)
Steven K. Libutti, Columbia Univ. College of Physicians and Surgeons (United States)
Thomas J. Kirby, Columbia Univ. College of Physicians and Surgeons (United States)
Craig R. Smith, Columbia Univ. College of Physicians and Surgeons (United States)
Michael R. Treat, Columbia Univ. College of Physicians and Surgeons (United States)


Published in SPIE Proceedings Vol. 1200:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems II
Stephen N. Joffe; Kazuhiko Atsumi, Editor(s)

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