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Proceedings Paper

New diagnostic method for squamous cell carcinoma using argon ion laser
Author(s): Akinori Nagasawa; Kazuichi Katoh
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Paper Abstract

The authors attempted laser therapies for squamous cell carcinoma combined with the chemotherapy in bleomycin (BLEO) intending to reinforce the therapeutic effect. Based on the result of the spectral analysis on the target tissues, argon ion laser (Ark laser) was selected for this photocheinotherapy. Following the intravenous administration of BLEO, the target tissue was exposed to the laser beam spot at low power density, and the laser treatment was repeated on all over the affected site including the surrounding normal part. The photochemotherapy regimen was repeated at every therapeutic session with twice the interval of administration of BLEO as usual. In spite of the reduction of the usual dosage of BLEO by half, remarkable therapeutic effect was assured at an early stage in the photochemotherapy session, and the tumor was reduced with increase in the therapeutic sessions. In addition to the successful therapeutic result, the following interesting phenomenon was noticed in the photochemotherapy regimen. When the target tissue was observed during exposure to the laser beam with reduction of the hyperbrightness of the reflection of the laser beam through an appropriate ND filter, the reflective image of the laser beam in the tumor site showed comparatively darker than that of normal part. The reflection image data on the targets to the laser beam were processed to the brightness profiles using a computer, and the results assured that the brightness contrast in the reflective image between the tumor site and the normal part was sufficient for discriminating the cancerous site from the normal part. The advantages of this diagnostic method are suninarized as follows : New method for visual capture of cancerous area, ® Simplicity in technique and examination system, ® Easy operation, J Non-invasive and complete safety. The result of this experiment hopefully proposes a new imaging diagnostic method for imilignant tumors depending on the optical characteristics.

Paper Details

Date Published: 1 May 1994
PDF: 10 pages
Proc. SPIE 2163, Medical Imaging 1994: Physics of Medical Imaging, (1 May 1994); doi: 10.1117/12.174279
Show Author Affiliations
Akinori Nagasawa, Tokai Univ. (Japan)
Kazuichi Katoh, Shibaura Institute of Technology (Japan)


Published in SPIE Proceedings Vol. 2163:
Medical Imaging 1994: Physics of Medical Imaging
Rodney Shaw, Editor(s)

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