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Proceedings Paper

Monitoring of fermentation parameters with fiber optics
Author(s): Venetka I. Agayn; David R. Walt
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Paper Abstract

Bioprocess control requires reliable and continuous monitoring of nutrients and various process parameters, such as dissolved oxygen, carbon dioxide, and pH. Currently, the on-line control of these parameters is achieved electrochemically via dip-in electrodes or indirectly by off-gas analysis. Optical sensors offer an alternative to these conventional methods. Fiber- optic sensors for measuring pH, CO2 and O2 have been developed. We have demonstrated the use of a fiber-optic sensor for the continuous monitoring of fermentation pH. In this paper we discuss the use of a ratiometric method and medium calibration as a way to improve the precision of the fiber-optic sensor.

Paper Details

Date Published: 10 March 1994
PDF: 6 pages
Proc. SPIE 2068, Chemical, Biochemical, and Environmental Fiber Sensors V, (10 March 1994); doi: 10.1117/12.170688
Show Author Affiliations
Venetka I. Agayn, Tufts Univ. (United States)
David R. Walt, Tufts Univ. (United States)


Published in SPIE Proceedings Vol. 2068:
Chemical, Biochemical, and Environmental Fiber Sensors V
Robert A. Lieberman, Editor(s)

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