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Proceedings Paper

Photodynamic detection and treatment of squamous cell carcinoma
Author(s): Sandor G. Vari; Vani R. Pergadia; Thanassis Papaioannou; Wendy J. Snyder; J. Marcus; Edward Glassberg; L. Dimino-Emme; Michael C. Fishbein; Reem Thomas; M. D. Dhondt; Gary P. Lask; Warren S. Grundfest
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Paper Abstract

In this study the fluorescence intensity of photosensitizer in squamous cell tumors were quantified in terms of the tumor resolution rate. A He-Cd laser (442 nm - 17 mW) with a 600 micrometers core silica fiber was used for excitation. The same fiber was used for fluorescence acquisition and an optical multichannel analyzer (EG&G, OMA III) was used to analyze the fluorescence. Twelve days after carcinoma inoculation fluorescence signal from the tumor and skin (1 cm radius from the tumor) at the 12, 3, 6, and 9 o'clock positions were recorded. Benzoporphyrin Derivative (QLT, Canada -- 2 mg/kg of body weight) was then injected into the tail vein. The drug was photoactivated with a 690 nm modified argon pump cw-dye laser (Medtech) operating at 140 mW/cm2 for 15 mins. LIFS is capable of localizing in situ malignancy and evaluating photosensitizers for photodynamic fluorescence detection and therapy of tumors.

Paper Details

Date Published: 15 February 1994
PDF: 10 pages
Proc. SPIE 2086, Medical Applications of Lasers, (15 February 1994); doi: 10.1117/12.169148
Show Author Affiliations
Sandor G. Vari, Cedars-Sinai Medical Ctr. (United States)
Vani R. Pergadia, Cedars-Sinai Medical Ctr. (United States)
Thanassis Papaioannou, Cedars-Sinai Medical Ctr. (United States)
Wendy J. Snyder, Cedars-Sinai Medical Ctr. (United States)
J. Marcus, UCLA/School of Medicine (United States)
Edward Glassberg, UCLA/School of Medicine (United States)
L. Dimino-Emme, UCLA/School of Medicine (United States)
Michael C. Fishbein, Cedars-Sinai Medical Ctr. (United States)
Reem Thomas, Cedars-Sinai Medical Ctr. (United States)
M. D. Dhondt, Cedars-Sinai Medical Ctr. (United States)
Gary P. Lask, UCLA School of Medicine (United States)
Warren S. Grundfest, Cedars-Sinai Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2086:
Medical Applications of Lasers
Kazuhiko Atsumi; Cornelius Borst; Frank W. Cross; Herbert J. Geschwind; Dieter Jocham; Jan Kvasnicka; Hans H. Scherer; Mario A. Trelles; Eberhard Unsoeld, Editor(s)

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