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Proceedings Paper

Differentiation of artery wall lesions using porphyrins and fiberoptic sensor in rabbits
Author(s): Sandor G. Vari; Maurits J. van der Veen; Theodore G. Papazoglou; Michael C. Fishbein; Marigo Stavridi; Thanassis Papaioannou; Warren S. Grundfest
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Paper Abstract

We investigated the ability of fluorescence spectroscopy, and photosensitizers to differentiate normal, hyperplastic and atherosclerotic arterial wall lesions in vivo. Hyperplastic lesions were induced in the abdominal aorta (AB) of 24 rabbits by balloon injury (BI). Atherosclerotic arterial wall lesions were induced by BI and diet. Fluorescence signals from thoracic n equals 16 and AB n equals 15 sites were analyzed by computer. A ratio was used as an index of drug presence. Use of PPS or BPD and LIFS may be a feasible, in vivo method for the differentiation between normal, hyperplastic and atherosclerotic arterial wall lesions.

Paper Details

Date Published: 15 February 1994
PDF: 9 pages
Proc. SPIE 2086, Medical Applications of Lasers, (15 February 1994); doi: 10.1117/12.169112
Show Author Affiliations
Sandor G. Vari, Cedars-Sinai Medical Ctr. (United States)
Maurits J. van der Veen, State Univ. Utrecht (Netherlands)
Theodore G. Papazoglou, Foundation for Research and Technology-Hellas (FO.R.T.H.) (Greece)
Michael C. Fishbein, Cedars-Sinai Medical Ctr. (United States)
Marigo Stavridi, Cedars-Sinai Medical Ctr. (United States)
Thanassis Papaioannou, Cedars-Sinai Medical Ctr. (United States)
Warren S. Grundfest, Cedars-Sinai Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2086:
Medical Applications of Lasers
Kazuhiko Atsumi; Cornelius Borst; Frank W. Cross; Herbert J. Geschwind; Dieter Jocham; Jan Kvasnicka; Hans H. Scherer; Mario A. Trelles; Eberhard Unsoeld, Editor(s)

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