Proceedings PaperComputer database for clinical and experimental photodynamic therapy data
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An outstanding problem in clinical photodynamic therapy (PDT) of cancer is the application of experimental and previous case studies to the prediction of doses and treatment regimes. The problem derives partly from the fact that several sets of data are incomplete and are not accessible during the course of the treatment of an individual patient. The objective of the computer database project is to provide an enabling utility to support decision making and also to analyze objectively pharmacokinetic, chemical pathological and clinical data with a view to identifying previously unrecognized correlations. The database has been initially developed using a data set from a number of clinical studies to assess the pharmacokinetic profiles of the PDT agents being used. It can be used to create a PDT treatment advice knowledge based system, relating to useful treatment strategies for PDT, and insights into areas of research in terms of isolating critical parameters of PDT.