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Proceedings Paper

Possibilities and limitations in chemical modeling of the primary processes in photodynamic therapy
Author(s): Tamas Vidoczy; Zsolt Kuti; Saleh Elzemzam; Dezso Gal
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Paper Abstract

The reactivity of the triplet state photosensitizer (hematoporphyrin) has been studied in model systems (homogeneous solutions). Preliminary experiments show that stable free radicals are consumed during interactions with triplet hematoporphyrin. These results combined with data in the literature enable the calculation of the relative importance of the interaction between the free radical and the triplet sensitizer as compared to the energy transfer from the triplet to ground state oxygen producing singlet oxygen. Our data are confirmed by direct measurements on the quantum yield of singlet oxygen in the absence and in the presence of stable free radicals.

Paper Details

Date Published: 1 March 1994
PDF: 8 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168702
Show Author Affiliations
Tamas Vidoczy, Central Research Institute for Chemistry (Hungary)
Zsolt Kuti, Central Research Institute for Chemistry (Hungary)
Saleh Elzemzam, Central Research Institute for Chemistry (Hungary)
Dezso Gal, Central Research Institute for Chemistry (Hungary)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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