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Proceedings Paper

Meso-tetra (4-carboxyphenyl) porphyrin--fluorescence behavior, photodynamic treatment, and tissue distribution
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Paper Abstract

Athymic nude mice with subcutaneously xenotransplanted urothelial carcinoma received intravenously injections of the synthetic sensitizer meso-tetra (4-carboxyphenyl) porphyrin. Fluorescence at the tumors and the skin was excited using a Kr+ laser (407 nm) and was detected at 652 nm using a fiberoptical sensor in combination with an optical multichannel analyzer at different times after application of the sensitizer. Photodynamic treatment was carried out using an Ar+ laser pumped dye laser (650 nm; 100 mW/cm2; 100 J/cm2). The delay of tumor growth was determined in a follow-up period of four weeks and was correlated to the in vivo fluorescence measurements.

Paper Details

Date Published: 1 March 1994
PDF: 6 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168699
Show Author Affiliations
Wolfgang S. L. Strauss, Institut fuer Lasertechnologien in der Medizin (Germany)
Werner Mohr, Univ. Ulm (Germany)
Karsten Koenig, Institut fuer Lasertechnologien in der Medizin (Germany)
Kurt Miller, Freie Univ. Berlin (Germany)
Angelika C. Rueck, Institut fuer Lasertechnologien in der Medizin (Germany)
Herbert Schneckenburger, Institut fuer Lasertechnologien in der Medizin (Germany)
Rudolf W. Steiner, Institut fuer Lasertechnologien in der Medizin (Germany)


Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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