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Proceedings Paper

New liposome-bound Ge(IV)-phthalocyanine (CGP 55398) for photodynamic therapy of tumors: preliminary studies
Author(s): Anna Segalla; G. Re; Carla Milanesi; Giulio Jori; Hans-Georg Capraro; Klaus Schieweck; Ute Isele
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Paper Abstract

A phthalocyanine derivative with two cholesterol moieties as axial ligands to the central Ge(IV) ion efficiently photosensitizes the oxidative modification of L-tryptophan. Administration of liposome-bound GePc to Balb/c mice bearing a MS-2 fibrosarcoma yields a quantitative release of the dye to serum lipoproteins, followed by a selective accumulation in the tumor as well as a low content in the skin. At 24 h after injection of 0.76 mg/kg GePc, the tumor was irradiated with 600 - 700 nm light; tumor necrosis appeared in all treated mice as a consequence of extensive damage of cellular and stromal elements.

Paper Details

Date Published: 1 March 1994
PDF: 6 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168697
Show Author Affiliations
Anna Segalla, Univ. of Padova (Italy)
G. Re, Univ. of Padova (Italy)
Carla Milanesi, Univ. of Padova (Italy)
Giulio Jori, Univ. of Padova (Italy)
Hans-Georg Capraro, CIBA-GEIGY Ltd. (Switzerland)
Klaus Schieweck, CIBA-GEIGY Ltd. (Switzerland)
Ute Isele, CIBA-GEIGY Ltd. (Switzerland)


Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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