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Proceedings Paper

Photodynamic therapy: light dosimetry and laser-induced tissue temperature phenomena
Author(s): Natalia Filonenko; Y. Gurevich; Norman M. Salansky
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Paper Abstract

Laser induced localized temperature distribution control in tissue could for instance provide in the targeted (e.g. tumor) area maximum sets of values to be used in efficacy increase for photodynamic therapy (PD) and hyperthermia (HT) applications. Spatial temperature distribution calculation method based on analytical solution of heat transfer equation is presented for laser induced heating and external tissue surface cooling combination. This method was applied to provide maximum temperature increase in deep tissue layers. Analytical relations for laser beam parameters and temperature threshold diagrams are obtained. These diagrams are to be used to avoid tissue burn. Examples of temperature increase in deep tissue layers are presented.

Paper Details

Date Published: 1 March 1994
PDF: 10 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168692
Show Author Affiliations
Natalia Filonenko, Univ. of Toronto (Canada)
Y. Gurevich, Univ. of Toronto (Canada)
Norman M. Salansky, Univ. of Toronto (Canada)


Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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