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Proceedings Paper

Prospects of radical-interacting porphyrin photosensitizers and their possible use in photodynamic therapy
Author(s): Dezso Gal; T Shuliakovskaya; Tamas Vidoczy; Saleh Elzemzam; Gabor Vasvari; L. Suemegi; Zsolt Kuti
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Paper Abstract

Based on literature data obtained in various fields with respect to studies on the role of free radicals in biology and on the kinetics of triplet-doublet interactions, it is suggested that excited photosensitizers react in vivo with free radicals formed in malignant tissues during photodynamic therapy (PDT) and this interaction competes with sensitizer-radical + molecule and the singlet oxygen mediated effects. Experimental results by laser flash photolysis and electron spin resonance revealed that sensitizer applied in PDT react with stable free radicals presumably both by energy transfer and electron transfer.

Paper Details

Date Published: 1 March 1994
PDF: 10 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168684
Show Author Affiliations
Dezso Gal, Central Research Institute for Chemistry (Hungary)
T Shuliakovskaya, Central Research Institute for Chemistry (Hungary)
Tamas Vidoczy, Central Research Institute for Chemistry (Hungary)
Saleh Elzemzam, Central Research Institute for Chemistry (Hungary)
Gabor Vasvari, Central Research Institute for Chemistry (Hungary)
L. Suemegi, Central Research Institute for Chemistry (Hungary)
Zsolt Kuti, Central Research Institute for Chemistry (Hungary)


Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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