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Proceedings Paper

Pharmaceutical development of CGP 55847: a liposomal Zn-phthalocyanine formulation using a controlled organic solvent dilution method
Author(s): Ute Isele; Peter van Hoogevest; Hans Leuenberger; Hans-Georg Capraro; Klaus Schieweck
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Paper Abstract

Liposomes were prepared containing zinc-phthalocyanine (ZnPc). The composition was ZnPc/POPC/OOPS (1:90:10 w/w /w). The phospholipids (PL) were dissolved in t-butanol at 50 degree(s)C under magnetic stirring and mixed with ZnPc, dissolved in NMP for two hours in an ultrasonic bath at 80 degree(s)C. This mixture (50 degree(s)C) was diluted with lactose- NaCl solution (9.475% lactose, 0.027% NaCl) at 4 degree(s)C using a dynamic mixer. The collected liposomal suspension was concentrated first, to 20 mg PL/ml suspension and then the organic solvents were removed by tangential flow filtration (CentrasetteR) against a ten fold volume of lactose-NaCl solution. After sterile filtration the liposomal suspension was freeze-dried for 24 hours.

Paper Details

Date Published: 1 March 1994
PDF: 7 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168680
Show Author Affiliations
Ute Isele, CIBA-GEIGY Ltd. and Univ. of Basle (Switzerland)
Peter van Hoogevest, CIBA-GEIGY Ltd. (Switzerland)
Hans Leuenberger, Univ. of Basle (Switzerland)
Hans-Georg Capraro, CIBA-GEIGY Ltd. (Switzerland)
Klaus Schieweck, CIBA-GEIGY Ltd. (Switzerland)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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