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Proceedings Paper

Induction of protoporphyrin biosynthesis and photodynamic inactivation of B16 melanoma cells
Author(s): Zvi Malik; T. Babushkina; M. Shafran; Y. Nordenberg; R. Mamet; N. Schoenfeld
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Paper Abstract

The induction of protoporphyrin (PP) synthesis in B16 melanoma cells and their subsequent photodestruction was investigated. Photosensitized cells gradually disintegrated following prolonged irradiation. The photosensitized cells showed an immediate potassium loss compensated only partially by influx of Na and other ions. The dominant characteristics of these cells were potassium efflux, water influx and ultrastructural damage in subcellular compartments. In conclusion, a highly efficient system for killing B16 melanoma cells was achieved by photosensitization of endogenous PP produced subsequent to chemical induction.

Paper Details

Date Published: 1 March 1994
PDF: 8 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168674
Show Author Affiliations
Zvi Malik, Bar-Ilan Univ. (Israel)
T. Babushkina, Bar-Ilan Univ. (Israel)
M. Shafran, Beilinson Medical Ctr. (Israel)
Y. Nordenberg, Beilinson Medical Ctr. (Israel)
R. Mamet, Beilinson Medical Ctr. (Israel)
N. Schoenfeld, Beilinson Medical Ctr. (Israel)


Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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