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Proceedings Paper

Photochemical inactivation of viruses by antibody conjugates of compounds generating singlet oxygen
Author(s): Alexander P. Savitsky; Andrey I. Tourkin; Elena V. Tourkina; Tatyana V. Cherednikova; Gely V. Ponomarev; Boris F. Poglazov
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Paper Abstract

For the first time a method is proposed for targeted destruction of viral particles with a photoimmuno-toxin. The photoinununotoxin is a conjugate of antibodies and dimethoxy haematoporphyrin (a potent singlet oxygen generator), binding with the viral particle and upon illumination with visible light inactivating the virus by singlet oxygen. The method can be used to combat viral infection in humans and to prevent lysis of industrial micro-organisms by lysogenic bacteriophage strains.

Paper Details

Date Published: 1 March 1994
PDF: 4 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168670
Show Author Affiliations
Alexander P. Savitsky, Institute of Biochemistry (Russia)
Andrey I. Tourkin, Institute of Biochemistry (Russia)
Elena V. Tourkina, Institute of Biochemistry (Russia)
Tatyana V. Cherednikova, Institute of Biochemistry (Russia)
Gely V. Ponomarev, Institute of Biochemistry (Russia)
Boris F. Poglazov, Institute of Biochemistry (Russia)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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