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Proceedings Paper

Subcellular distribution of photodynamic sensitizers
Author(s): Herbert Schneckenburger; Michael H. Gschwend; Karsten Koenig; Angelika C. Rueck; Reinhard Sailer; Wolfgang S. L. Strauss
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Paper Abstract

Various microscopic methods were established to measure the subcellular distribution and light-induced reactions of photosensitizing porphyrins. These methods include high resolution video microscopy, microspectrofluorometry, as well as time-resolved and time-gated fluorescence spectroscopy. By using these techniques, different components of hydrophylic and hydrophobic photosensitizers (e.g. monomers, aggregates, ionic species) were localized, and their intracellular reactions -- re-distribution, formation of photoproducts, pH-dependent spectral changes -- were studied.

Paper Details

Date Published: 1 March 1994
PDF: 7 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168661
Show Author Affiliations
Herbert Schneckenburger, Univ. Ulm and Fachhochschule Aalen (Germany)
Michael H. Gschwend, Univ. Ulm (Germany)
Karsten Koenig, Univ. Ulm (Germany)
Angelika C. Rueck, Univ. Ulm (Germany)
Reinhard Sailer, Univ. Ulm (Germany)
Wolfgang S. L. Strauss, Univ. Ulm (Germany)


Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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