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Proceedings Paper

Biodistribution detection of Photofrin porfimer sodium and benzoporphyrin derivative using a fiber optic sensor and ratio fluorometry
Author(s): Sandor G. Vari; Theodore G. Papazoglou; Thanassis Papaioannou; Marigo Stavridi; Vani R. Pergadia; Michael C. Fishbein; Maurits J. van der Veen; Reem Thomas; Warren S. Grundfest
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Paper Abstract

Laser induced fluorescence spectroscopy (LIFS) was used to detect the presence of PHOTOFRINR porfimer sodium and Benzoporphyrin derivative-monoacid, ring A (BPD-MA) in various tissues. Lobund Wistar rats (n equals 49) inoculated with rat prostatic adenocarcinoma (PA-III) were injected with PHOTOFRINR porfimer sodium (7.5 - 0.25 mg/kg) and BPD (0.50 - 25 mg/kg) intravenously. A Helium-Cadmium laser (442 nm) was used as an excitation source. Our study showed that the amount of PHOTOFRINR porfimer sodium and BPD-MA which localizes in the metastatic lymph nodes is higher than in tumor and all other healthy tissues. Laser induced fluorescence spectroscopy may be a feasible method to detect the distribution of photosensitizers or other fluorescent compounds in vivo.

Paper Details

Date Published: 1 March 1994
PDF: 10 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168656
Show Author Affiliations
Sandor G. Vari, Cedars-Sinai Medical Ctr. (United States)
Theodore G. Papazoglou, Foundation for Research and Technology-Hellas (Greece)
Thanassis Papaioannou, Cedars-Sinai Medical Ctr. (United States)
Marigo Stavridi, Cedars-Sinai Medical Ctr. (United States)
Vani R. Pergadia, Cedars-Sinai Medical Ctr. (United States)
Michael C. Fishbein, Cedars-Sinai Medical Ctr. (United States)
Maurits J. van der Veen, State Univ. Utrecht School of Medicine (Netherlands)
Reem Thomas, Cedars-Sinai Medical Ctr. (United States)
Warren S. Grundfest, Cedars-Sinai Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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