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Proceedings Paper

Synthesis and biological evaluation of a series of new germanium phthalocyanines incorporated into liposomes--part II: biological evaluation
Author(s): Klaus Schieweck; Hans-Georg Capraro; Ute Isele; Ernst Batt; Martin Ochsner; Peter van Hoogevest; William G. Love
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Paper Abstract

The pharmacokinetic and phototherapeutic properties of new phthalocyanines with Ge(IV) or Si(VI) as the central metal ion and cholesterol, cholestan or long-chain fatty acids residues as axial ligands to the central ion have been studied in tumor-bearing mice. The new photosensitizers were selectively taken up by and relatively quickly released from the tumors. Except for Si(IV)-Pc, which showed a comparably high selectivity for tumor versus peritumoral tissue, all Ge(IV)-Pc were less selective than liposomal Zn-Pc (CGP 55847). However, all the new compounds showed excellent phototherapeutic efficiency at very low drug and light doses in studies in Meth-A-sarcoma-bearing mice.

Paper Details

Date Published: 1 March 1994
PDF: 6 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168649
Show Author Affiliations
Klaus Schieweck, CIBA-GEIGY Ltd. (Switzerland)
Hans-Georg Capraro, CIBA-GEIGY Ltd. (Switzerland)
Ute Isele, CIBA-GEIGY Ltd. (Switzerland)
Ernst Batt, CIBA-GEIGY Ltd. (Switzerland)
Martin Ochsner, CIBA-GEIGY Ltd. (Switzerland)
Peter van Hoogevest, CIBA-GEIGY Ltd. (Switzerland)
William G. Love, CIBA-GEIGY Pharmaceuticals (United Kingdom)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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