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Proceedings Paper

Laser photothermolysis of single blood vessels in the chick chorioallantoic membrane (CAM)
Author(s): Sol Kimel; Lars Othar Svaasand; Thomas E. Milner; Marie J. Hammer-Wilson; Michael J. Schell; J. Stuart Nelson; Michael W. Berns
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Paper Abstract

Individual blood vessels in the chick chorioallantoic membrane (CAM) were selectively coagulated through photothermolysis, using pulsed laser irradiation at 585 nm. Pulse durations were chosen to be 0.45 ms and 10 ms, which correspond to the thermal relaxation times in blood vessels of 30 micrometers and 150 micrometers diameter, respectively. The dose vs diameter (D vs d) relationship for coagulation was calculated for the two pulse shapes. The energy deposited in a cylindrical absorber of diameter d by an optical field, incident perpendicular to the vessel, was expressed analytically and compared with the energy required to coagulate a blood vessel of the same lumen diameter. When thermal diffusion is incorporated into the model, our findings can be accounted for quantitatively. This information will be of use for improving the laser treatment of port wine stains and other vasculopathies.

Paper Details

Date Published: 1 February 1994
PDF: 12 pages
Proc. SPIE 2077, Laser Interaction with Hard and Soft Tissue, (1 February 1994); doi: 10.1117/12.168033
Show Author Affiliations
Sol Kimel, Technion--Israel Institute of Technology (Israel)
Lars Othar Svaasand, Univ. of Trondheim (Norway)
Thomas E. Milner, Beckman Laser Institute and Medical Clinic (United States)
Marie J. Hammer-Wilson, Beckman Laser Institute and Medical Clinic (United States)
Michael J. Schell, Univ. of California/Irvine (United States)
J. Stuart Nelson, Univ. of California/Irvine (United States)
Michael W. Berns, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 2077:
Laser Interaction with Hard and Soft Tissue

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