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Proceedings Paper

Low-power interstitial laser photocoagulation for breast cancer
Author(s): Simon A. Harries; Zahir Amin; William R. Lees; J. Cooke; Mark Smith; Martin Cook; John H. Scurr; Mark W. Kissin; Stephen G. Bown
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Paper Abstract

Interstitial laser photocoagulation (ILP) is a new minimally invasive technique which can produce localized necrosis in the center of solid organs. Breast cancer can now be treated safely in selected patients by lumpectomy followed by radiotherapy. Taking the concept of conservative treatment a step further would it be possible to destroy breast cancers in situ leaving the area to heal by resorption and fibrosis? Thirty seven patients with early breast cancer scheduled for surgery underwent ILP in the interval between diagnosis and surgery. The technique was performed under local anaesthesia, and ultrasound (US) used to place an optical fiber into the tumor. Treatment was curtailed in 4 patients because of pain. Thermal necrosis varied from 2 - 25 mm as measured microscopically but in 4 patients no necrosis was evident. No complications arose as a result of treatment. When charring was present in the excised tumor a larger diameter of necrosis was evident than when charring was absent (mean 15 mm vs 5 mm) and a study in 10 patients using a pre-charred fiber produced a more predictable and larger diameter of necrosis (mean 17 mm). Ultrasound did not accurately predict the extent of laser induced necrosis (although it was better at predicting tumor size).

Paper Details

Date Published: 1 February 1994
PDF: 8 pages
Proc. SPIE 2077, Laser Interaction with Hard and Soft Tissue, (1 February 1994); doi: 10.1117/12.168018
Show Author Affiliations
Simon A. Harries, Univ. College London Medical School (United Kingdom)
Zahir Amin, Univ. College London Medical School (United Kingdom)
William R. Lees, Univ. College London Medical School (United Kingdom)
J. Cooke, Royal Surrey County Hospital (United Kingdom)
Mark Smith, Univ. College London Medical School (United Kingdom)
Martin Cook, Royal Surrey County Hospital (United Kingdom)
John H. Scurr, Univ. College London Medical School (United Kingdom)
Mark W. Kissin, Royal Surrey County Hospital (United Kingdom)
Stephen G. Bown, Univ. College London Medical School (United Kingdom)


Published in SPIE Proceedings Vol. 2077:
Laser Interaction with Hard and Soft Tissue
Martin J. C. van Gemert; Rudolf W. Steiner; Lars Othar Svaasand; Hansjoerg Albrecht, Editor(s)

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