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Proceedings Paper

Transcutaneous bilirubinometry during phototherapy
Author(s): Laura Ronchi; Giovanni Agati; Franco Fusi; Riccardo Pratesi
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Paper Abstract

Transcutaneous bilirubinometry based on reflectance spectroscopy technique requires the modelling of bilirubin photochemistry and metabolism in skin, and the solution of inverse problems to derive pigment concentrations from spectral measurements. The influence of bilirubin photochemistry occurring during the initial stage of phototherapy on the reflectance spectrum of an icteric tissue is analyzed using a 5-layer skin model, and an algorithm is presented to evaluate bilirubin concentration during phototherapy. An in vivo reflectance spectrum during phototherapy is presented where the configurational, reversible photoisomerization of bilirubin is observed for the first time.

Paper Details

Date Published: 1 February 1994
PDF: 11 pages
Proc. SPIE 2084, Biomedical Optoelectronic Devices and Systems, (1 February 1994); doi: 10.1117/12.167307
Show Author Affiliations
Laura Ronchi, IROE-CNR (Italy)
Giovanni Agati, IEQ-CNR (Italy)
Franco Fusi, IEQ-CNR (Italy)
Riccardo Pratesi, Univ. di Firenze and Area della Ricerca-CNR (Italy)


Published in SPIE Proceedings Vol. 2084:
Biomedical Optoelectronic Devices and Systems
Nathan I. Croitoru; Riccardo Pratesi, Editor(s)

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