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Proceedings Paper

Fluorescence studies of 5-aminolaevulinic acid induced protoporphyrin IX and sulphonated aluminium phthalocyanine tissue distributions
Author(s): Alexander J. MacRobert; M. D. Judd; Jaroslaw Regula; C. S. Loh; Stephen G. Brown
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Paper Abstract

A quantitative technique based on fluorescence microscopic detection has been developed for measurements of photosensitizer distributions in frozen tissue sections using a highly sensitive charge-coupled device camera. Studies have been carried out on sulphonated aluminum phthalocyanine and Protoporphyrin IX induced by administration of exogenous 5-aminolaevulinic acid. This technique has enabled microscopic pharmacokinetic studies to be performed in a range of normal tissues and tumors in order to improve our understanding of the photosensitization mechanism and enable optimal treatment times and dosimetry to be determined. Comparisons with chemical extraction data are reviewed and the feasibility of using biopsies from patients for optimizing dosimetry is discussed.

Paper Details

Date Published: 15 January 1994
PDF: 8 pages
Proc. SPIE 2081, Optical Biopsy, (15 January 1994); doi: 10.1117/12.166836
Show Author Affiliations
Alexander J. MacRobert, Univ. College London (United Kingdom)
M. D. Judd, Univ. College London (United Kingdom)
Jaroslaw Regula, Univ. College London (United Kingdom)
C. S. Loh, Univ. College London (United Kingdom)
Stephen G. Brown, Rayne Institute (United Kingdom)

Published in SPIE Proceedings Vol. 2081:
Optical Biopsy
Rinaldo Cubeddu; Sune Svanberg; Hubert van den Bergh, Editor(s)

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