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Proceedings Paper

Optical diagnostics based on elastic scattering: recent clinical demonstrations with the Los Alamos optical biopsy system
Author(s): Irving J. Bigio; Thomas R. Loree; Judith R. Mourant; Tsutomu Shimada; K. Story-Held; Randolph D. Glickman; Richard L. Conn
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Paper Abstract

A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. In addition to the reduced invasiveness of this technique compared with current state-of-the-art methods (surgical biopsy and pathology analysis), the OBS offers the possibility of impressively faster diagnostic assessment.

Paper Details

Date Published: 15 January 1994
PDF: 11 pages
Proc. SPIE 2081, Optical Biopsy, (15 January 1994); doi: 10.1117/12.166823
Show Author Affiliations
Irving J. Bigio, Los Alamos National Lab. (United States)
Thomas R. Loree, Los Alamos National Lab. (United States)
Judith R. Mourant, Los Alamos National Lab. (United States)
Tsutomu Shimada, Los Alamos National Lab. (United States)
K. Story-Held, Univ. of Texas Health Sciences Ctr. (United States)
Randolph D. Glickman, Univ. of Texas (United States)
Richard L. Conn, Lovelace Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2081:
Optical Biopsy
Rinaldo Cubeddu; Sune Svanberg; Hubert van den Bergh, Editor(s)

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