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Proceedings Paper

Clinical comparison of the pharmacokinetics of m-THPC and Photofrin II as observed by light-induced fluorescence
Author(s): Daniel Braichotte; Jean-Francois Savary; Georges A. Wagnieres; A. Mudry; Charlotte Fontolliet; Philippe Monnier; Hubert van den Bergh
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Paper Abstract

To optimize phototherapy and photodetection of cancer, one of the important variables is the localization of the dye after injection. To study this in a clinical context, we have constructed an apparatus based on a non-invasive optical fiber that detects the dye by light induced fluorescence. The time course of the fluorescence signal can be used directly for optimizing photodetection. However, complementary information on the detailed localization of the drug by fluorescence microscopy, and a correlation of this data with tumor necrosis efficacy, are necessary to optimize PDT timing. This will be demonstrated for the case of Photofrin II and tetra (meta- hydroxyphenyl) chlorin (mTHPC) and the two sets of data will be compared.

Paper Details

Date Published: 15 January 1994
PDF: 12 pages
Proc. SPIE 2081, Optical Biopsy, (15 January 1994); doi: 10.1117/12.166811
Show Author Affiliations
Daniel Braichotte, Ecole Polytechnique Federale de Lausanne (Switzerland)
Jean-Francois Savary, CHUV Hospital (Switzerland)
Georges A. Wagnieres, Ecole Polytechnique de Federale Lausanne (Switzerland)
A. Mudry, CHUV Hospital (Switzerland)
Charlotte Fontolliet, Univ. of Lausanne (Switzerland)
Philippe Monnier, CHUV Hospital (Switzerland)
Hubert van den Bergh, Ecole Polytechnique Federale de Lausanne (Switzerland)

Published in SPIE Proceedings Vol. 2081:
Optical Biopsy

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