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Proceedings Paper

Alzheimer's disease: neuritic plaques and neurofibrillary tangles in human brain identified by FT-IR spectroscopy
Author(s): Lin-P'ing Choo; Michael Jackson; William C. Halliday; Henry H. Mantsch
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Paper Abstract

The abnormal abundance of (beta) -amyloid plaques and neurofibrillary tangles are the hallmark of Alzheimer's disease (AD). Human central nervous system (CNS) grey matter was probed for characteristics arising from these pathological features. In AD but not normal grey matter, an IR band at 1615 cm-1 is seen, characteristic of a protein in an aggregated state. We speculate that this band arises from (beta) A4-amyloid protein. AD, and 18q- grey matter spectra show increased intensity of phosphate bands in accordance with known hyperphosphorylation of proteins found in neurofibrillary tangles. These spectral features may be useful in the diagnosis of AD.

Paper Details

Date Published: 31 January 1994
PDF: 2 pages
Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); doi: 10.1117/12.166733
Show Author Affiliations
Lin-P'ing Choo, National Research Council Canada (Canada)
Michael Jackson, National Research Council Canada (Canada)
William C. Halliday, Health Science Ctr. (Canada)
Henry H. Mantsch, National Research Council Canada (Canada)


Published in SPIE Proceedings Vol. 2089:
9th International Conference on Fourier Transform Spectroscopy
John E. Bertie; Hal Wieser, Editor(s)

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