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Proceedings Paper

Infrared spectroscopic characterization of human white matter, grey matter, and multiple sclerosis lesions
Author(s): Lin-P'ing Choo; Michael Jackson; William C. Halliday; Henry H. Mantsch
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Paper Abstract

FT-IR spectroscopy has been used to characterize white matter, grey matter, and multiple sclerosis (MS) plaques from human central nervous system (CNS) tissue. Discrimination among these three tissue types is possible due to variations in composition. Spectra of white matter exhibit strong lipid absorptions. In contrast, spectra of grey matter reveal a reduced lipid contribution and a significant absorption from water. MS plaques exhibit spectra indicative of lipid loss and, depending upon whether the plaques are chronic or acute, changes in the protein and/or water content.

Paper Details

Date Published: 31 January 1994
PDF: 2 pages
Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); doi: 10.1117/12.166686
Show Author Affiliations
Lin-P'ing Choo, National Research Council Canada (Canada)
Michael Jackson, National Research Council Canada (Canada)
William C. Halliday, Health Science Ctr. (Canada)
Henry H. Mantsch, National Research Council Canada (Canada)


Published in SPIE Proceedings Vol. 2089:
9th International Conference on Fourier Transform Spectroscopy
John E. Bertie; Hal Wieser, Editor(s)

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