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Proceedings Paper

Structural characterization and nanometer-scale domain formation in phospholipid model membranes by infrared spectroscopy and scanning tunneling microscopy
Author(s): Brian W. Gregory; Richard A. Dluhy; Lawrence A. Bottomley
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Paper Abstract

Research in this laboratory is presently being conducted towards the structural characterization of well-ordered molecular monolayers using an integrated spectroscopic/imaging approach. We are currently using infrared spectroscopy (IR) in combination with scanning tunneling microscopy (STM) on both Langmuir-Blodgett (L-B) and self-assembled (SA) monolayer films in order to obtain compositional, conformational, and topographic information about these films. We have constructed organized lipid bilayer assemblies using a combination of SA and L-B methods which were studied using this combined IR/STM approach. These studies showed acyl chain tilt angles of 5 - 10 degree(s) within the DPPG monolayer by IR and STM. In addition, nanometer-size DPPG with hexagonal-type grain boundaries, and molecular resolution of phosphoglycerol headgroup structure within these domains, have been observed by STM. Phospholipid headgroup areas are in excellent agreement with previous x-ray diffraction studies of this system.

Paper Details

Date Published: 31 January 1994
PDF: 2 pages
Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); doi: 10.1117/12.166605
Show Author Affiliations
Brian W. Gregory, Univ. of Georgia (United States)
Richard A. Dluhy, Univ. of Georgia (United States)
Lawrence A. Bottomley, Georgia Institute of Technology (United States)


Published in SPIE Proceedings Vol. 2089:
9th International Conference on Fourier Transform Spectroscopy

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