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Proceedings Paper

XeCl excimer laser-induced autofluorescence spectroscopy for human cerebral tumor diagnosis: preliminary study
Author(s): Sigrid Avrillier; Frederic Hor; Michel Desgeorges; Dominique Ettori; Jean Robert Sitbon
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Paper Abstract

Three-hundred-eight nm laser-induced autofluorescence spectra of the normal human brain, astrocytoma grade IV and glioblastoma grade IV specimens, have been recorded in vitro two hours after surgical resection. Typical fluorescence spectra for normal (N) and malignant (M) tissue show 4 maxima at about 352, 362, 383, and 460 nm. These spectra are analyzed in detail. Subtle differences in normalized spectra of N and M tissues appear to be large enough for diagnosis. Several criteria such as maxima and minima absolute intensity and intensity ratios at typical wavelengths are computed and used to classify the tissue. This preliminary study shows that fluorescence spectroscopy with 308 nm UV excitation could be a valid technique for discriminating tumor types. However, it should be noted that these measurements are made in vitro. Living tissues may have different spectral characteristics, therefore future in vivo investigations must be performed.

Paper Details

Date Published: 17 September 1993
PDF: 10 pages
Proc. SPIE 1894, Clinical Applications of Modern Imaging Technology, (17 September 1993); doi: 10.1117/12.154945
Show Author Affiliations
Sigrid Avrillier, Univ. Paris XIII (France)
Frederic Hor, Hopital du val de Grace (France)
Michel Desgeorges, Hopital du val de Grace (France)
Dominique Ettori, Univ. Paris XIII (France)
Jean Robert Sitbon, Univ. Paris XIII (France)

Published in SPIE Proceedings Vol. 1894:
Clinical Applications of Modern Imaging Technology
Abund Ottokar Wist, Editor(s)

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