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Proceedings Paper

Time-dependent photon migration imaging in two dimensions: a method for detection and localization of absorbers in tissuelike media
Author(s): Eva Marie Sevick-Muraca; Joan K. Frisoli; Christina L. Hutchinson; Henryk Szmacinski; Kazimierz Nowaczyk; Michael L. Johnson; Joseph R. Lakowicz
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Paper Abstract

Measurements of time-dependent photon migration appear to provide more information for biomedical optical image reconstruction than continuous wave measurements. Yet the ultimate success of photon migration imaging (PMI) for biomedical optical tomography depends upon developing a method which can rapidly measure `time-of-flight' information, and, in near-real time, extract important information required for image reconstruction. Image reconstruction requires information to (1) detect, (2) locate the position and volume, and (3) characterize the optical properties of an optical heterogeneity that would otherwise be obscured by tissue-like scattering. In this presentation, we report PMI `images' of an obscured absorber obtained from two-dimensional time-dependent photon migration measurements which arise from single point source illumination of a scattering medium with modulated light. These PMI `images' along with a theoretical basis for PMI, suggest the potential to rapidly detect and locate the three- dimensional position of an absorber from two-dimensional frequency-domain measurements of phase, (Theta) ((rho) ,f), and modulation, M((rho) ,f). Independent single-pixel measurements and Monte Carlo simulations of (Theta) ((rho) ,f) and M((rho) ,f) confirm the PMI `images' and the hypothesis for PMI.

Paper Details

Date Published: 14 September 1993
PDF: 12 pages
Proc. SPIE 1888, Photon Migration and Imaging in Random Media and Tissues, (14 September 1993); doi: 10.1117/12.154662
Show Author Affiliations
Eva Marie Sevick-Muraca, Vanderbilt Univ. (United States)
Joan K. Frisoli, Univ. of Maryland/Baltimore School of Medicine (United States)
Christina L. Hutchinson, Vanderbilt Univ. (United States)
Henryk Szmacinski, Univ. of Maryland/Baltimore School of Medicine (United States)
Kazimierz Nowaczyk, Univ. of Maryland/Baltimore School of Medicine (United States)
Michael L. Johnson, Univ. of Virginia School of Medicine (United States)
Joseph R. Lakowicz, Univ. of Maryland/Baltimore School of Medicine (United States)

Published in SPIE Proceedings Vol. 1888:
Photon Migration and Imaging in Random Media and Tissues
Britton Chance; Robert R. Alfano, Editor(s)

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