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Proceedings Paper

Monte Carlo simulation of light transport through inhomogeneous tissue
Author(s): Mutsuhisa Hiraoka; Michael Firbank; Matthias Essenpreis; Mark Cope; Simon Robert Arridge; Pieter van der Zee; David T. Delpy
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Paper Abstract

Quantitation of near infrared spectroscopic (NIRS) data requires an accurate knowledge of the effective optical pathlengths within the various components of an inhomogeneous scattering medium. For instance, in the monitoring of cerebral oxygenation by NIRS, the contribution of the overlying tissues such as the skin and the skull to the total optical pathlength must be known. To elucidate this problem a Monte Carlo model of light transport through a heterogeneous scattering and absorbing medium has been developed in which the boundaries of the heterogeneous media are concentric spheres. The inside medium represents brain tissue and the outside medium represent skin and skull. The Monte Carlo model uses an anisotropic scattering phase function and values for absorption coefficient ((mu) a) and scattering coefficient ((mu) s) in each medium that are based upon experimentally measured data. The model follows paths of photons from an input point to their exit on the medium boundary and calculates the total optical pathlength (the differential pathlength DP) and the pathlength in each medium. An analytical proof of the applicability of the Modified Beer-Lambert Law in a heterogeneous medium is also presented and the possible contribution of the overlying tissues of the head to the total NIRS signal is discussed.

Paper Details

Date Published: 14 September 1993
PDF: 11 pages
Proc. SPIE 1888, Photon Migration and Imaging in Random Media and Tissues, (14 September 1993); doi: 10.1117/12.154631
Show Author Affiliations
Mutsuhisa Hiraoka, Univ. College London (United Kingdom)
Michael Firbank, Univ. College London (United Kingdom)
Matthias Essenpreis, Univ. College London (United Kingdom)
Mark Cope, Univ. College London (United Kingdom)
Simon Robert Arridge, Univ. College London (United Kingdom)
Pieter van der Zee, Univ. of Hertfordshire (United Kingdom)
David T. Delpy, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 1888:
Photon Migration and Imaging in Random Media and Tissues
Britton Chance; Robert R. Alfano, Editor(s)

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