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Proceedings Paper

Pancreas tumor model in rabbit imaged by perfusion CT scans
Author(s): Jason Gunn; Kenneth Tichauer; Karen Moodie; Susan Kane; Jack Hoopes; Errol E. Stewart; Jennifer Hadway; Ting-Yim Lee; Stephen P. Pereira; Brian W. Pogue
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Paper Abstract

The goal of this work was to develop and validate a pancreas tumor animal model to investigate the relationship between photodynamic therapy (PDT) effectiveness and photosensitizer drug delivery. More specifically, this work lays the foundation for investigating the utility of dynamic contrast enhanced blood perfusion imaging to be used to inform subsequent PDT. A VX2 carcinoma rabbit cell line was grown in the tail of the pancreas of three New Zealand White rabbits and approximately 3-4 weeks after implantation the rabbits were imaged on a CT scanner using a contrast enhanced perfusion protocol, providing parametric maps of blood flow, blood volume, mean transit time, and vascular permeability surface area product.

Paper Details

Date Published: 13 March 2013
PDF: 6 pages
Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85681E (13 March 2013); doi: 10.1117/12.1518470
Show Author Affiliations
Jason Gunn, Thayer School of Engineering at Dartmouth (United States)
Kenneth Tichauer, Thayer School of Engineering at Dartmouth (United States)
Karen Moodie, Geisel School of Medicine (United States)
Susan Kane, Geisel School of Medicine (United States)
Jack Hoopes, Geisel School of Medicine (United States)
Errol E. Stewart, Western Univ. (Canada)
Jennifer Hadway, Western Univ. (Canada)
Ting-Yim Lee, Western Univ. (Canada)
Stephen P. Pereira, Univ. College London (United Kingdom)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Geisel School of Medicine (United States)


Published in SPIE Proceedings Vol. 8568:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
David H. Kessel; Tayyaba Hasan, Editor(s)

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