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Proceedings Paper

Measurement of physiological flow parameters with magnetic resonance
Author(s): Charles L. Dumoulin; M. Tarnawski; D. J. Doorly; C. G. Caro; R. D. Darrow
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Paper Abstract

Some phase-sensitive methods obtain a phase measurement for each voxel in an otherwise conventional image. In an alternative approach, data for a variety of flow-sensitive conditions are obtained and Fourier transformed to obtain a velocity 'spectrum'. Fourier velocity encoded data are highly accurate and are not degraded by velocity distributions within a voxel. One important application of Fourier velocity encoding is the non-invasive measurement of local vessel wall compliance. We have developed a new technique in which spin velocity information is acquired simultaneously for several stations along a vessel using a comb excitation rf pulse and Fourier velocity encoding. In the absence of pulse wave reflections, two stations separated by a sufficient distance are enough to calculate the velocity of the pressure wave, C. Once the wave velocity is known, it can be used to determine vessel wall distensibility, D, using the relationship D equals 1/((rho) C2), where (rho) is the density of blood. Preliminary data from a group of healthy volunteers suggest a strong correlation of local vessel compliance with physical fitness and age.

Paper Details

Date Published: 27 August 1993
PDF: 19 pages
Proc. SPIE 1887, Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods, (27 August 1993); doi: 10.1117/12.151198
Show Author Affiliations
Charles L. Dumoulin, GE Corporate Research and Development Ctr. (United States)
M. Tarnawski, Imperial College of Science Technology and Medicine (United Kingdom)
D. J. Doorly, Imperial College of Science Technology and Medicine (United Kingdom)
C. G. Caro, Imperial College of Science Technology and Medicine (United Kingdom)
R. D. Darrow, GE Corporate Research and Development Ctr. (United States)


Published in SPIE Proceedings Vol. 1887:
Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods
Randall Locke Barbour; Mark J. Carvlin, Editor(s)

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